A recent study from Johns Hopkins University has revealed an unexpected link between a chemical known to be responsible for the smell of human gas and protecting the brain from cognitive decline and Alzheimer’s disease. The New York Post reported that the research suggests that the gas “hydrogen sulfide (H₂S)” may have an important defensive role in the brain as we age.
Alzheimer’s Treatment
The researchers published their findings in the journal PNAS, where they conducted experiments on genetically engineered mice to simulate the symptoms of Alzheimer’s. The mice were regularly injected with a compound called “NaGYY,” which is a compound that carries hydrogen sulfide gas and slowly releases it into the body.
After 12 weeks of treatment, the scientists observed a significant improvement of up to 50% in the cognitive and motor abilities of the mice that received the compound, compared to the mice that were not treated. The results were described as amazing, as they suggest the possibility of reversing some aspects of the neurodegeneration associated with Alzheimer’s.
The researchers explain that levels of hydrogen sulfide gas in the body gradually decrease with age, which leads to the accumulation of tau protein in nerve cells, disruption in communication between cells, and ultimately nerve cell death.
Dr. Bindu Paul, one of the lead researchers, said:
“Our new data reveals a clear link between aging, neurodegeneration, and cell communication mechanisms via hydrogen sulfide gas and other cellular gases.”
“The next step will be to test the compound on humans to determine its effectiveness and safety, before considering the development of new treatments based on this approach.”
